Analytical Method Development and Validation of Exemestane Tablet by UV Spectrophotometry | Zendy

S. Angalaparameswari | Zendy; V. S. Thiruvengadarajan | Zendy; Naresh Kumar | Zendy; M. Kutumbarao | Zendy; S Ramkanth | Zendy; C. Madhusudhanachetty | Zendy

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Analytical Method Development and Validation of Exemestane Tablet by UV Spectrophotometry

Author(s) -

S. Angalaparameswari,

V. S. Thiruvengadarajan,

Naresh Kumar,

M. Kutumbarao,

S Ramkanth,

C. Madhusudhanachetty

Publication year - 2012

Publication title -

journal of chemistry

Language(s) - English

Resource type - Journals

eISSN - 2090-9063

pISSN - 2090-9071

DOI - 10.1155/2012/782738

Subject(s) - exemestane , spectrophotometry , chromatography , chemistry , medicine , cancer , breast cancer , aromatase

The present research work discusses the development and validation of a UV spectrophotometric method for Exemestane. Simple, accurate and cost efficient spectrophotometric method has been developed for the estimation of Exemestane in Tablet dosage form. The optimum conditions for the analysis of the drug were established. The maximum wavelength (λ max) was found to be 246 nm. The percentage recovery of Exemestane was in the 98.7±0.4. Beers law was obeyed in the concentration range of 2-14 µg/mL. Calibration curves shows a linear relationship between the absorbance and concentration. The line equation y=0.05954x+0.0000 with r2 of 0.9938 was obtained. Validation was performed according to ICH guidelines for Linearity, accuracy, precision, LOD and LOQ. The sample solution was stable up to 36 hours. The proposed method may be suitable for the analysis of Exemestane in tablet formulation for quality control purposes

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