Autophagy in Pancreatic Cancer | Zendy

Daniel Grasso | Zendy; María Noé Garcia | Zendy; Juan Iovanna | Zendy

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Autophagy in Pancreatic Cancer

Author(s) -

Daniel Grasso,

María Noé Garcia,

Juan Iovanna

Publication year - 2012

Publication title -

international journal of cell biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.587

H-Index - 53

eISSN - 1687-8884

pISSN - 1687-8876

DOI - 10.1155/2012/760498

Subject(s) - autophagy , pancreatic cancer , life expectancy , disease , medicine , bioinformatics , cancer research , cancer , biology , microbiology and biotechnology , genetics , apoptosis , population , environmental health

Pancreatic adenocarcinoma (PDAC) is a devastating disease with an extremely poor life expectancy and no effective treatment. Autophagy is a process of degradation of cytoplasmic component capable of recycling cellular components or eliminate specific targets. The presence of autophagy in PDAC has been demonstrated. However, the implicated cellular pathways are not fully understood and, more importantly, the role of autophagy in PDAC is matter of intensive debate. This review summarizes recently published data in an attempt to clarify the importance of autophagy in this disease and try to reconcile apparently contradictory results.

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