Mucin Production and Mucous Cell Metaplasia in Otitis Media | Zendy

Jizhen Lin | Zendy; Per CayéThomasen | Zendy; Tetsuya Tono | Zendy; Quanan Zhang | Zendy; Yoshihisa Nakamura | Zendy; Feng Ling | Zendy; Jianmin Huang | Zendy; Shengnan Ye | Zendy; Xiaohua Hu | Zendy; Joseph E. Kerschner | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Mucin Production and Mucous Cell Metaplasia in Otitis Media

Author(s) -

Jizhen Lin,

Per CayéThomasen,

Tetsuya Tono,

Quanan Zhang,

Yoshihisa Nakamura,

Feng Ling,

Jianmin Huang,

Shengnan Ye,

Xiaohua Hu,

Joseph E. Kerschner

Publication year - 2012

Publication title -

international journal of otolaryngology

Language(s) - English

Resource type - Journals

eISSN - 1687-921X

pISSN - 1687-9201

DOI - 10.1155/2012/745325

Subject(s) - mucin , middle ear , otitis , eustachian tube , medicine , effusion , metaplasia , pathology , immunology , anatomy , surgery

Otitis media (OM) with mucoid effusion, characterized by mucous cell metaplasia/hyperplasia in the middle ear cleft and thick fluid accumulation in the middle ear cavity, is a subtype of OM which frequently leads to chronic OM in young children. Multiple factors are involved in the developmental process of OM with mucoid effusion, especially disorders of mucin production resulting from middle ear bacterial infection and Eustachian tube dysfunction. In this review, we will focus on several aspects of this disorder by analyzing the cellular and molecular events such as mucin production and mucous cell differentiation in the middle ear mucosa with OM. In addition, infectious agents, mucin production triggers, and relevant signaling pathways will be discussed.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research