Antioxidant Stress and Anti-Inflammation of PPARαon Warm Hepatic Ischemia-Reperfusion Injury | Zendy

Zhixin Gao | Zendy; Yuanhai Li | Zendy

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Antioxidant Stress and Anti-Inflammation of PPARαon Warm Hepatic Ischemia-Reperfusion Injury

Author(s) -

Zhixin Gao,

Yuanhai Li

Publication year - 2012

Publication title -

ppar research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.164

H-Index - 49

eISSN - 1687-4765

pISSN - 1687-4757

DOI - 10.1155/2012/738785

Subject(s) - medicine , inflammation , antioxidant , ischemia , reperfusion injury , downregulation and upregulation , pharmacology , lipid metabolism , liver injury , immunology , chemistry , biochemistry , gene

Hepatic ischemia-reperfusion (IR) injury is a serious clinical problem. Minimizing the adverse effect of ischemia-reperfusion injury after liver surgery or trauma is an urgent need. It has been proved that besides the effect of regulating the lipid and lipoprotein metabolism, PPAR α also undertakes the task of organ protection. In this paper, related literature has been summarized and we come to the conclusion that administration of PPAR α agonists can strengthen the antioxidant and anti-inflammation defense system by the upregulation of the expression of antioxidant enzymes and inhibition of NF- κ B activity. This may provide a potential clinical treatment for hepatic ischemia-reperfusion injury.

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