In VitroAnti-CandidaActivity of Lidocaine and Nitroglycerin: Alone and Combined | Zendy

Ana PalmeiradeOliveira | Zendy; A.R. Ramos | Zendy; Carlos Gaspar | Zendy; Rita PalmeiradeOliveira | Zendy; P. Gouveia | Zendy; José MartinezdeOliveira | Zendy

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In VitroAnti-CandidaActivity of Lidocaine and Nitroglycerin: Alone and Combined

Author(s) -

Ana PalmeiradeOliveira,

A.R. Ramos,

Carlos Gaspar,

Rita PalmeiradeOliveira,

P. Gouveia,

José MartinezdeOliveira

Publication year - 2012

Publication title -

infectious diseases in obstetrics and gynecology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.656

H-Index - 48

eISSN - 1098-0997

pISSN - 1064-7449

DOI - 10.1155/2012/727248

Subject(s) - candida krusei , fluconazole , lidocaine , candida glabrata , pharmacology , candida albicans , candida parapsilosis , candida tropicalis , chemistry , in vitro , medicine , microbiology and biotechnology , antifungal , anesthesia , biology , biochemistry

The aim of this work was to study the anti-Candida activity of lidocaine and nitroglycerin alone and in combination. Ten Candida strains were included, corresponding to 1 collection type strain (ATCC 10231) and 9 clinical isolates: 4 C. albicans, 2 C. glabrata, 1 C. tropicalis, 1 C. krusei, and 1 C. parapsilosis. The CLSI reference M27-A3 micromethod was used to determine the anti-Candida activity of the drugs alone; minimal inhibitory and lethal concentrations were determined. The classic checkboard technique was used to determine the activity of combined drugs. Lidocaine fungicidal effect was dosedependent. Nitroglycerin exhibited a higher effect. The drugs combination resulted in a reduction of the inhibitory concentration, corresponding to an additive effect. In conclusion, both drugs exhibited an interesting anti-Candida activity. The combination of lidocaine with nitroglycerin was shown to have an additive effect against Candida spp., predicting the interest to include, in the future, these drugs in a new delivery system for the treatment of mucocutaneous candidosis

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