Alterations in Nitric Oxide Synthase in the Aged CNS | Zendy

Junyang Jung | Zendy; Changhyun Na | Zendy; Youngbuhm Huh | Zendy

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Alterations in Nitric Oxide Synthase in the Aged CNS

Author(s) -

Junyang Jung,

Changhyun Na,

Youngbuhm Huh

Publication year - 2012

Publication title -

oxidative medicine and cellular longevity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.494

H-Index - 93

eISSN - 1942-0900

pISSN - 1942-0994

DOI - 10.1155/2012/718976

Subject(s) - nitric oxide , nitric oxide synthase , oxidative stress , pathogenesis , neuroscience , senescence , aging brain , biology , neuronal nitric oxide synthase , ageing , microbiology and biotechnology , endocrinology , medicine , immunology , cognition

Aging is associated with neuronal loss, gross weight reduction of the brain, and glial proliferation in the cortex, all of which lead to functional changes in the brain. It is known that oxidative stress is a critical factor in the pathogenesis of aging; additionally, growing evidence suggests that excessive nitric oxide (NO) production contributes to the aging process. However, it is still unclear how NO plays a role in the aging process. This paper describes age-related changes in the activity of NADPH-diaphorase (NADPH-d), a marker for neurons containing nitric oxide synthase (NOS), in many CNS regions. Understanding these changes may provide a novel perspective in identifying the aging mechanism

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