Early Detection Biomarkers for Ovarian Cancer
Author(s) -
Sreeja Sarojini,
Ayala Tamir,
Heejin Lim,
Shihong Li,
Shifang Zhang,
André Goy,
Andrew L. Pecora,
K. Stephen Suh
Publication year - 2012
Publication title -
journal of oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.228
H-Index - 54
eISSN - 1687-8469
pISSN - 1687-8450
DOI - 10.1155/2012/709049
Subject(s) - ovarian cancer , medicine , biomarker , disease , malignancy , cancer , oncology , carcinogenesis , biology , biochemistry
Despite the widespread use of conventional and contemporary methods to detect ovarian cancer development, ovarian cancer remains a common and commonly fatal gynecological malignancy. The identification and validation of early detection biomarkers highly specific to ovarian cancer, which would permit development of minimally invasive screening methods for detecting early onset of the disease, are urgently needed. Current practices for early detection of ovarian cancer include transvaginal ultrasonography, biomarker analysis, or a combination of both. In this paper we review recent research on novel and robust biomarkers for early detection of ovarian cancer and provide specific details on their contributions to tumorigenesis. Promising biomarkers for early detection of ovarian cancer include KLK6/7, GSTT1, PRSS8, FOLR1, ALDH1, and miRNAs.
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