Synthesis, Characterization andIn VitroAntibacterial Studies of Organotin(IV) Complexes with 2-Hydroxyacetophenone-2-methylphenylthiosemicarbazone ()

Five new organotin(IV) complexes of 2-hydroxyacetophenone-2-methylphenylthiosemicarbazone [H 2 dampt, ( 1 )] with formula [RSnCl n-1 (dampt)] (where R = Me, n = 2 ( 2 ); R = Bu, n = 2 ( 3 ); R = Ph, n = 2 ( 4 ); R = Me 2 , n = 1 ( 5 ); R = Ph 2 , n = 1 ( 6 )) have been synthesized by direct reaction of H 2 dampt ( 1 ) with organotin(IV) chloride(s) in absolute methanol. The ligand ( 1 ) and its organotin(IV) complexes ( 2–6 ) were characterized by CHN analyses, molar conductivity, UV-Vis, FT-IR, 1 H, 13 C, and 119 Sn NMR spectral studies. H 2 dampt ( 1 ) is newly synthesized and has been structurally characterized by X-ray crystallography. Spectroscopic data suggested that H 2 dampt ( 1 ) is coordinated to the tin(IV) atom through the thiolate-S, azomethine-N, and phenoxide-O atoms; the coordination number of tin is five. The in vitro antibacterial activity has been evaluated against Staphylococcus aureus, Enterobacter aerogenes, Escherichia coli , and Salmonella typhi . The screening results have shown that the organotin(IV) complexes ( 2–6 ) have better antibacterial activities and have potential as drugs. Furthermore, it has been shown that diphenyltin(IV) derivative ( 6 ) exhibits significantly better activity than the other organotin(IV) derivatives ( 2–5 ).