Intracranial Metastatic Neuroblastoma Treated with Gamma Knife Stereotactic Radiosurgery: Report of Two Novel Cases | Zendy

Nathan C. Rowland | Zendy; J.R. Andrews | Zendy; Daxa Patel | Zendy; David V. LaBorde | Zendy; Adam Nowlan | Zendy; Bradley George | Zendy; Claire Mazewski | Zendy; Andrew Reisner | Zendy; Howard M. Katzenstein | Zendy

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Intracranial Metastatic Neuroblastoma Treated with Gamma Knife Stereotactic Radiosurgery: Report of Two Novel Cases

Author(s) -

Nathan C. Rowland,

J.R. Andrews,

Daxa Patel,

David V. LaBorde,

Adam Nowlan,

Bradley George,

Claire Mazewski,

Andrew Reisner,

Howard M. Katzenstein

Publication year - 2012

Publication title -

case reports in neurological medicine

Language(s) - English

Resource type - Journals

eISSN - 2090-6668

pISSN - 2090-6676

DOI - 10.1155/2012/690548

Subject(s) - medicine , radiosurgery , radiation therapy , neuroblastoma , radiology , surgery , biology , genetics , cell culture

Intracranial metastasis of neuroblastoma (IMN) is associated with poor survival. No curative therapy for the treatment of IMN currently exists. Unfractionated radiotherapy may be beneficial in the treatment of IMN given the known radiosensitivity of neuroblastoma as well as its proclivity to metastasize as discrete lesions. We present two patients with IMN treated with Gamma Knife stereotactic radiosurgery (SRS). Single-fraction radiotherapy yielded temporary reduction of tumor burden and stability of disease in both patients. SRS may be a useful palliative tool in the treatment of IMN and expands the overall treatment options for this disease.

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