The Role of PPARγinHelicobacter pyloriInfection and Gastric Carcinogenesis

Peroxisome proliferator-activated receptor γ (PPAR γ ) is a nuclear receptor that is important in many physiological and pathological processes, such as lipid metabolism, insulin sensitivity, inflammation, cell proliferation, and carcinogenesis. Several studies have shown that PPAR γ plays an important role in gastric mucosal injury due to Helicobacter pylori ( H. pylori ). As H. pylori infection is the main etiologic factor in chronic gastritis and gastric cancer, understanding of the potential roles of PPAR γ in H. pylori infection may lead to the development of a therapeutic target. In this paper, the authors discuss the current knowledge on the role of PPAR γ in H. pylori infection and its related gastric carcinogenesis.