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Osseous Metaplasia in Castleman's Disease: A Case Report
Author(s) -
Maral Mokhtari,
Perikala V. Kumar
Publication year - 2012
Publication title -
case reports in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.2
H-Index - 20
eISSN - 1687-9627
pISSN - 1687-9635
DOI - 10.1155/2012/674870
Subject(s) - medicine , pathology , hyaline , germinal center , hyaline cartilage , mantle zone , castleman disease , plasma cell , metaplasia , lymphatic system , disease , anatomy , b cell , bone marrow , antibody , alternative medicine , osteoarthritis , articular cartilage , immunology
Background . Castleman's disease is a benign lymphoproliferative disorder. The disease may be localized or multicentric. Three histologic variants are recognized: hyaline vascular, plasma cell, and mixed types. Case . A 20-year-old man presented with large left axillary mass. The histologic examination of the resected mass showed follicular pattern with large nodules of mantle cells arranged concentrically around atrophic and vascularized germinal centers. There was also some benign-appearing bone trabeculae interspersed with lymphoid tissue. The diagnosis of Castleman's disease, hyaline-vascular type with osseous metaplasia, was made.

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