Complete Remission of Methotrexate-Related Epstein-Barr-Virus-Associated Hodgkin-Like Lymphoma following Withdrawal of MTX Coupled with Clarithromycin Administration | Zendy

Nobuo Takemori | Zendy; Hiroyuki Kaneko | Zendy; Masaya Nakamura | Zendy; Masaru Kojima | Zendy

Open Access

Complete Remission of Methotrexate-Related Epstein-Barr-Virus-Associated Hodgkin-Like Lymphoma following Withdrawal of MTX Coupled with Clarithromycin Administration

Author(s) -

Nobuo Takemori,

Hiroyuki Kaneko,

Masaya Nakamura,

Masaru Kojima

Publication year - 2012

Publication title -

case reports in hematology

Language(s) - English

Resource type - Journals

eISSN - 2090-6560

pISSN - 2090-6579

DOI - 10.1155/2012/658745

Subject(s) - medicine , methotrexate , clarithromycin , rheumatoid arthritis , lymphoma , epstein–barr virus , virus , immunology , gastroenterology , helicobacter pylori

Patients with rheumatoid arthritis (RA) are known to develop lymphoproliferative disorders (LPDs) during the course of illness, particularly in cases treated with methotrexate (MTX) for long periods. We describe a case of MTX-related Epstein-Barr-virus-(EBV-) associated LPD resembling Hodgkin's lymphoma (HL), in which a dramatic complete remission was achieved after withdrawal of MTX coupled with clarithromycin (CAM) administration. Withdrawal of MTX coupled with CAM administration seemed to be effective for treating MTX-related EBV-associated LPDs. In particular, an immunomodulative effect of CAM might have been involved in achieving complete remission.

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