Nitric Oxide Manipulation: A Therapeutic Target for Peripheral Arterial Disease? | Zendy

Gareth Williams | Zendy; Shiwen Xu | Zendy; David Abraham | Zendy; Sadasivam Selvakumar | Zendy; Daryll Baker | Zendy; Janice Tsui | Zendy

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Nitric Oxide Manipulation: A Therapeutic Target for Peripheral Arterial Disease?

Author(s) -

Gareth Williams,

Shiwen Xu,

David Abraham,

Sadasivam Selvakumar,

Daryll Baker,

Janice Tsui

Publication year - 2012

Publication title -

cardiology research and practice

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.437

H-Index - 35

eISSN - 2090-8016

pISSN - 2090-0597

DOI - 10.1155/2012/656247

Subject(s) - medicine , asymmetric dimethylarginine , nitric oxide , peripheral , arterial disease , pathophysiology , disease , amputation , vascular disease , intensive care medicine , surgery , cardiology , arginine , biochemistry , chemistry , amino acid

Peripheral Arterial Disease (PAD) is a cause of significant morbidity and mortality in the Western world. Risk factor modification and endovascular and surgical revascularisation are the main treatment options at present. However, a significant number of patients still require major amputation. There is evidence that nitric oxide (NO) and its endogenous inhibitor asymmetric dimethylarginine (ADMA) play significant roles in the pathophysiology of PAD. This paper reviews experimental work implicating the ADMA-DDAH-NO pathway in PAD, focussing on both the vascular dysfunction and effects within the ischaemic muscle, and examines the potential of manipulating this pathway as a novel adjunct therapy in PAD.

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