Perspectives on the Role of Photodynamic Therapy in the Treatment of Pancreatic Cancer | Zendy

Wei Li | Zendy; Qingyong Ma | Zendy; Erxi Wu | Zendy

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Perspectives on the Role of Photodynamic Therapy in the Treatment of Pancreatic Cancer

Author(s) -

Wei Li,

Qingyong Ma,

Erxi Wu

Publication year - 2011

Publication title -

international journal of photoenergy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.426

H-Index - 51

eISSN - 1687-529X

pISSN - 1110-662X

DOI - 10.1155/2012/637429

Subject(s) - photodynamic therapy , pancreatic cancer , autophagy , cancer research , reactive oxygen species , apoptosis , medicine , programmed cell death , cancer , cancer treatment , necrosis , cancer cell , chemistry , pathology , biochemistry , organic chemistry

Photodynamic therapy (PDT) is a noninvasive procedure involving a photosensitizing agent that is activated by light to produce reactive oxygen species (ROS) that selectively destroy tumor cells. In recent years, PDT has been used in the treatment of pancreatic cancer (PC). The antitumor effects of PDT include three main mechanisms: direct tumor cell death (necrosis, apoptosis, and autophagy), vascular destruction, and immune system activation. The present paper systematically summarizes the effects of PDT in the treatment of PC from the experimental studies to the clinical studies and discusses the mechanisms of PDT-induced PC destruction

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