Antibody-Dependent Cellular Cytotoxicity and NK Cell-Driven Immune Escape in HIV Infection: Implications for HIV Vaccine Development | Zendy

Gamze Isitman | Zendy; Ivan Stratov | Zendy; Stephen J. Kent | Zendy

Open Access

Antibody-Dependent Cellular Cytotoxicity and NK Cell-Driven Immune Escape in HIV Infection: Implications for HIV Vaccine Development

Author(s) -

Gamze Isitman,

Ivan Stratov,

Stephen J. Kent

Publication year - 2012

Publication title -

advances in virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.956

H-Index - 25

eISSN - 1687-8647

pISSN - 1687-8639

DOI - 10.1155/2012/637208

Subject(s) - antibody dependent cell mediated cytotoxicity , immune system , antibody , immunology , cytotoxicity , cytotoxic t cell , biology , virology , hiv vaccine , immune escape , virus , human immunodeficiency virus (hiv) , monoclonal antibody , vaccine trial , genetics , in vitro

The HIV-1 genome is malleable and a difficult target tot vaccinate against. It has long been recognised that cytotoxic T lymphocytes and neutralising antibodies readily select for immune escape HIV variants. It is now also clear that NK cells can also select for immune escape. NK cells force immune escape through both direct Killer-immunoglobulin-like receptor (KIR)-mediated killing as well as through facilitating antibody-dependent cellular cytotoxicity (ADCC). These newer finding suggest NK cells and ADCC responses apply significant pressure to the virus. There is an opportunity to harness these immune responses in the design of more effective HIV vaccines.

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