Expedient Protocols for the Installation of Pyrimidine Based Privileged Templates on 2‐Position of Pyrrolo[2,1‐c][1,4]‐benzodiazepine Nucleus Linked Through a p‐phenoxyl Spacer | Zendy

Anshu Agarwal | Zendy; Meenakshi Sharma | Zendy; Meenakshi Agrawal | Zendy; D. Kishore | Zendy

Open Access

Expedient Protocols for the Installation of Pyrimidine Based Privileged Templates on 2‐Position of Pyrrolo[2,1‐c][1,4]‐benzodiazepine Nucleus Linked Through a p‐phenoxyl Spacer

Author(s) -

Anshu Agarwal,

Meenakshi Sharma,

Meenakshi Agrawal,

D. Kishore

Publication year - 2012

Publication title -

journal of chemistry

Language(s) - English

Resource type - Journals

eISSN - 2090-9063

pISSN - 2090-9071

DOI - 10.1155/2012/629414

Subject(s) - pyrimidine , nucleus , template , position (finance) , benzodiazepine , chemistry , combinatorial chemistry , stereochemistry , computer science , nanotechnology , neuroscience , materials science , psychology , biochemistry , business , receptor , finance

Exceedingly facile single step expedient protocols based on the versatility and reactivity of corresponding intermediates : [2-(dimethylaminomethylene) ketone] (5) and chalcone (6), derived from 2-(p-acetyl phenoxyl) substituted analogue of pyrrolo[2,1-c][1,4]-benzodiazepine (4), have been developed to provide an easy installation of the pyrimidine based privileged templates at 2-position of pyrrolo[2,1-c][1,4]-benzodiazepine through a p-phenoxyl spacer, by utilizing the synthetic strategy depicted in schemes-1 and 2

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