Susceptibility to Toxoplasmic Retinochoroiditis Is Associated with Hla Alleles Reported to Be Implicated with Rapid Progression to Aids | Zendy

Ana Lúcia G. Demarco | Zendy; Maria de Lourdes Veronese Rodrigues | Zendy; José Fernando C. Figueiredo | Zendy; Neifi Hassam Saloum Deghaide | Zendy; Marcelo Bezerra de Menezes | Zendy; Luís A. Demarco | Zendy; Ana Paula Fernandes | Zendy; Eduardo Antônio Donadi | Zendy

Open Access

Susceptibility to Toxoplasmic Retinochoroiditis Is Associated with Hla Alleles Reported to Be Implicated with Rapid Progression to Aids

Author(s) -

Ana Lúcia G. Demarco,

Maria de Lourdes Veronese Rodrigues,

José Fernando C. Figueiredo,

Neifi Hassam Saloum Deghaide,

Marcelo Bezerra de Menezes,

Luís A. Demarco,

Ana Paula Fernandes,

Eduardo Antônio Donadi

Publication year - 2012

Publication title -

disease markers

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.912

H-Index - 66

eISSN - 1875-8630

pISSN - 0278-0240

DOI - 10.1155/2012/612030

Subject(s) - human leukocyte antigen , immunology , toxoplasmosis , antibody , allele , toxoplasma gondii , hla b , medicine , virology , biology , antigen , genetics , gene

Background/aims : The frequency of HLA markers associated with rapid progression to AIDS was evaluated in Brazilian patients with AIDS exhibiting or not toxoplasmic retinochoroiditis (TRC). Methods : 98 AIDS patients (25 with TRC, 43 with anti- T . gondii antibodies but without TCR, and 30 without anti- T . gondii antibodies and without TCR) were studied. Results : The HLA-B35 was significantly increased in TRC group ( p = 0.0038). Conclusion : The presence of HLA-B35 may simultaneously predispose to progression to AIDS and TRC.

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