MicroRNAs in Acute Myeloid Leukemia and Other Blood Disorders | Zendy

Yuan Yao | Zendy; Siddha Kasar | Zendy; Chingiz Underbayev | Zendy; Sindhuri Prakash | Zendy; Elizabeth Raveché | Zendy

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MicroRNAs in Acute Myeloid Leukemia and Other Blood Disorders

Author(s) -

Yuan Yao,

Siddha Kasar,

Chingiz Underbayev,

Sindhuri Prakash,

Elizabeth Raveché

Publication year - 2012

Publication title -

leukemia research and treatment

Language(s) - English

Resource type - Journals

eISSN - 2090-3219

pISSN - 2090-3227

DOI - 10.1155/2012/603830

Subject(s) - medicine , microrna , chronic lymphocytic leukemia , myeloid leukemia , immunology , leukemia , dyscrasia , plasma cell dyscrasia , autoantibody , immune system , antibody , plasma cell , biology , biochemistry , immunoglobulin light chain , gene

Common blood disorders include hematopoietic cell malignancies or leukemias and plasma cell dyscrasia, all of which have associated microRNA abnormalities. In this paper, we discuss several leukemias including acute myeloid leukemia (AML) and chronic lymphocytic leukemia (CLL) and identify altered microRNAs and their targets. Immune disorders with altered blood levels of antibodies include autoimmune disorders, such as systemic lupus erythematosus (SLE) with associated anti-self-autoantibodies and immunoglobulin A nephropathy (IgAN) also have related microRNA abnormalities. The alterations in microRNAs may serve as therapeutic targets in these blood disorders.

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