Synthesis Characterization and DNA Interaction Studies of a New Zn(II) Complex Containing Different Dinitrogen Aromatic Ligands | Zendy

Nahid Shahabadi | Zendy; Somaye Mohammadi | Zendy

Open Access

Synthesis Characterization and DNA Interaction Studies of a New Zn(II) Complex Containing Different Dinitrogen Aromatic Ligands

Author(s) -

Nahid Shahabadi,

Somaye Mohammadi

Publication year - 2012

Publication title -

bioinorganic chemistry and applications

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.865

H-Index - 35

eISSN - 1565-3633

pISSN - 1687-479X

DOI - 10.1155/2012/571913

Subject(s) - chemistry , ethidium bromide , intercalation (chemistry) , circular dichroism , cyclic voltammetry , zinc , proton nmr , crystallography , bromide , dna , phenanthroline , fluorescence , bipyridine , nuclear chemistry , stereochemistry , inorganic chemistry , organic chemistry , electrochemistry , biochemistry , physics , crystal structure , electrode , quantum mechanics

A mononuclear complex of Zn(II), [Zn(DIP) 2 (DMP)] (NO 3 ) 2 · 2H 2 O in which DIP is 4,7-diphenyl-1,10-phenanthroline and DMP is 4,4′-dimethyl-2,2′-bipyridine has been prepared and characterized by 1 HNMR spectroscopy, FT-IR, UV-Vis and elemental analysis techniques. DNA-binding properties of the complex were studied using UV-vis spectra, circular dichroism (CD) spectra, fluorescence, cyclic voltammetry (CV), and viscosity measurements. The results indicate that this zinc(II) complex can intercalate into the stacked base pairs of DNA and compete with the strong intercalator ethidium bromide for the intercalative binding sites.

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