Advances in Alcoholic Liver Disease | Zendy

Natalia A. Osna | Zendy; Kusum K. Kharbanda | Zendy; Laura W. Schrum | Zendy; Angela Dolganiuc | Zendy

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Advances in Alcoholic Liver Disease

Author(s) -

Natalia A. Osna,

Kusum K. Kharbanda,

Laura W. Schrum,

Angela Dolganiuc

Publication year - 2012

Publication title -

international journal of hepatology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.734

H-Index - 14

eISSN - 2090-3448

pISSN - 2090-3456

DOI - 10.1155/2012/563018

Subject(s) - alcoholic liver disease , hepatic stellate cell , pathogenesis , medicine , liver injury , hepatocyte , liver disease , secretion , disease , pathology , cirrhosis , biology , in vitro , biochemistry

This special issue reflects on multiple factors/mechanisms involved in the pathogenesis of ALD. Alcoholic liver injury is known to cause a broad range of liver abnormalities. Alcohol is primarily metabolized in the hepatocyte leading to increased secretion of inflammatory mediators, which, in turn, activate and/or influence the response of the nonparenchymal cells (NPCs) (hepatic stellate cells, Kupffer cells, and sinusoidal endothelial cells) and subsequently control the degree of liver injury.

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