Role of Adipokines and Other Inflammatory Mediators in Gestational Diabetes Mellitus and Previous Gestational Diabetes Mellitus | Zendy

Nikolaos Vrachnis | Zendy; P. Belitsos | Zendy; Stavros Sifakis | Zendy; Konstantinos Dafopoulos | Zendy; Charalampos Siristatidis | Zendy; Kalliopi I. Pappa | Zendy; Zoi Iliodromiti | Zendy

Open Access

Role of Adipokines and Other Inflammatory Mediators in Gestational Diabetes Mellitus and Previous Gestational Diabetes Mellitus

Author(s) -

Nikolaos Vrachnis,

P. Belitsos,

Stavros Sifakis,

Konstantinos Dafopoulos,

Charalampos Siristatidis,

Kalliopi I. Pappa,

Zoi Iliodromiti

Publication year - 2012

Publication title -

international journal of endocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.875

H-Index - 60

eISSN - 1687-8345

pISSN - 1687-8337

DOI - 10.1155/2012/549748

Subject(s) - medicine , resistin , adipokine , adiponectin , gestational diabetes , leptin , diabetes mellitus , endocrinology , type 2 diabetes mellitus , retinol binding protein 4 , adipose tissue , insulin resistance , pathogenesis , metabolic syndrome , obesity , pregnancy , gestation , biology , genetics

Previous Gestational Diabetes Mellitus (pGDM) is a common condition and has been associated with future development of Type 2 Diabetes Mellitus (T2DM) and Metabolic Syndrome (MS) in women affected. The pathogenesis and risk factors implicated in the development of these conditions later in the lives of women with pGDM are not as yet fully understood. Research has recently focused on a group of substances produced mainly by adipose tissue called adipokines, this group including, among others, adiponectin, leptin, Retinol-Binding Protein-4 (RBP-4), and resistin. These substances as well as other inflammatory mediators (CRP, IL-6, PAI-1, TNF- α ) seem to play an important role in glucose tolerance and insulin sensitivity dysregulation in women with pGDM. We summarize the data available on the role of these molecules.

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