DTI and MR Volumetry of Hippocampus-PC/PCC Circuit: In Search of Early Micro- and Macrostructural Signs of Alzheimers's Disease | Zendy

Fulvia Palesi | Zendy; Paolo Vitali | Zendy; Patrizia Chiarati | Zendy; Gloria Castellazzi | Zendy; Eduardo Caverzasi | Zendy; Anna Pichiecchio | Zendy; E. Colli-Tibaldi | Zendy; F D'Amore | Zendy; I. D'Errico | Zendy; Elena Sinforiani | Zendy; Stefano Bastianello | Zendy

Open Access

DTI and MR Volumetry of Hippocampus-PC/PCC Circuit: In Search of Early Micro- and Macrostructural Signs of Alzheimers's Disease

Author(s) -

Fulvia Palesi,

Paolo Vitali,

Patrizia Chiarati,

Gloria Castellazzi,

Eduardo Caverzasi,

Anna Pichiecchio,

E. Colli-Tibaldi,

F D'Amore,

I. D'Errico,

Elena Sinforiani,

Stefano Bastianello

Publication year - 2011

Publication title -

neurology research international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.365

H-Index - 31

eISSN - 2090-1852

pISSN - 2090-1860

DOI - 10.1155/2012/517876

Subject(s) - fractional anisotropy , medicine , precuneus , diffusion mri , white matter , nuclear medicine , hippocampal formation , algorithm , magnetic resonance imaging , computer science , radiology , functional magnetic resonance imaging

Hippocampal damage, by DTI or MR volumetry, and PET hypoperfusion of precuneus/posterior cingulate cortex (PC/PCC) were proposed as biomarkers of conversion from preclinical (MCI) to clinical stage of Alzheimer's disease (AD). This study evaluated structural damage, by DTI and MR volumetry, of hippocampi and tracts connecting hippocampus to PC/PCC (hipp-PC/PCC) in 10 AD, 10 MCI, and 18 healthy controls (CTRL). Normalized volumes, mean diffusivity (MD), and fractional anisotropy (FA) were obtained for grey matter (GM), white matter (WM), hippocampi, PC/PCC, and hipp-PC/PCC tracts. In hippocampi and hipp-PC/PCC tracts, decreased volumes and increased MD were found in AD versus CTRL ( P < .001). The same results with lower significance ( P < .05) were found in MCI versus CTRL. Verbal memory correlated ( P < .05) in AD with left hippocampal and hipp-PC/PCC tract MD, and in MCI with FA of total WM. Both DTI and MR volumetry of hippocampi and hipp-PC/PCC tracts detect early signs of AD in MCI patients.

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