Acute Generalized Exanthematous Pustulosis due to Tocilizumab in a Rheumatoid Arthritis Patient | Zendy

Jorge Hernán Izquierdo | Zendy; Fabio BonillaAbadía | Zendy; Carlos Darío Ochoa | Zendy; Andrés Agualimpia | Zendy; Gabriel J. Tobón | Zendy; Carlos A. Cañas | Zendy

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Acute Generalized Exanthematous Pustulosis due to Tocilizumab in a Rheumatoid Arthritis Patient

Author(s) -

Jorge Hernán Izquierdo,

Fabio BonillaAbadía,

Carlos Darío Ochoa,

Andrés Agualimpia,

Gabriel J. Tobón,

Carlos A. Cañas

Publication year - 2012

Publication title -

case reports in rheumatology

Language(s) - English

Resource type - Journals

eISSN - 2090-6889

pISSN - 2090-6897

DOI - 10.1155/2012/517424

Subject(s) - tocilizumab , medicine , acute generalized exanthematous pustulosis , leflunomide , rheumatoid arthritis , methotrexate , dermatology , adverse effect , surgery

We report a female patient with rheumatoid arthritis which was refractory to methotrexate, leflunomide, and anti-TNF therapy. She was treated with anti-IL-6 tocilizumab (TCZ), with an early appearance of sterile pustules on erythematous swollen skin of trunk, back, and abdominal area. The lesions were consistent with the diagnosis of acute drug-related generalized exanthematous pustulosis (AGEP). This adverse event was controlled with medical treatment without requiring removal of TCZ.

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