Integrin Trafficking and Tumor Progression | Zendy

Sejeong Shin | Zendy; Laura Wolgamott | Zendy; Sang-Oh Yoon | Zendy

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Integrin Trafficking and Tumor Progression

Author(s) -

Sejeong Shin,

Laura Wolgamott,

Sang-Oh Yoon

Publication year - 2011

Publication title -

international journal of cell biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.587

H-Index - 53

eISSN - 1687-8884

pISSN - 1687-8876

DOI - 10.1155/2012/516789

Subject(s) - integrin , extracellular matrix , metastasis , endocytosis , cancer research , microbiology and biotechnology , tumor progression , cell adhesion , medicine , cancer , biology , cell , genetics

Integrins are major mediators of cancer cell adhesion to extracellular matrix. Through this interaction, integrins play critical roles in cell migration, invasion, metastasis, and resistance to apoptosis during tumor progression. Recent studies highlight the importance of integrin trafficking, endocytosis and recycling, for the functions of integrins in cancer cells. Understanding the molecular mechanisms of integrin trafficking is pivotal for understanding tumor progression and for the development of anticancer drugs.

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