Interface Molecules ofAngiostrongylus cantonensis: Their Role in Parasite Survival and Modulation of Host Defenses | Zendy

Alessandra Loureiro Morassutti | Zendy; Carlos Graeff-Teixeira | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Interface Molecules ofAngiostrongylus cantonensis: Their Role in Parasite Survival and Modulation of Host Defenses

Author(s) -

Alessandra Loureiro Morassutti,

Carlos Graeff-Teixeira

Publication year - 2012

Publication title -

international journal of inflammation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.106

H-Index - 33

eISSN - 2090-8040

pISSN - 2042-0099

DOI - 10.1155/2012/512097

Subject(s) - angiostrongylus cantonensis , angiostrongyliasis , eosinophil , meningoencephalitis , host (biology) , pathogen , biology , immunology , proinflammatory cytokine , inflammation , medicine , parasite hosting , asthma , helminths , ecology , world wide web , computer science

Angiostrongylus cantonensis is a nematode parasite that causes eosinophilic meningoencephalitis in humans. Disease presents following the ingestion of third-stage larvae residing in the intermediate mollusk host and disease manifests as an acute inflammation of the meninges characterized by eosinophil infiltrates which release a battery of proinflammatory and cytotoxic agents in response to the pathogen. As a mechanism of neutralizing these host defenses, A. cantonensis expresses different molecules with immunomodulatory properties that are excreted or secreted (ES). In this paper we discuss the role of ES proteins on disease exacerbation and their potential use as therapeutic targets.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research