A Brief Review of Chronic Obstructive Pulmonary Disease | Zendy

James C. Hogg | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

A Brief Review of Chronic Obstructive Pulmonary Disease

Author(s) -

James C. Hogg

Publication year - 2012

Publication title -

canadian respiratory journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.675

H-Index - 53

eISSN - 1916-7245

pISSN - 1198-2241

DOI - 10.1155/2012/496563

Subject(s) - medicine , copd , lung transplantation , lung , pulmonary disease , obstructive lung disease , airway , airway obstruction , pulmonary function testing , computed tomography , lung function , pathology , radiology , surgery

A recent study, based on a combination of multidetector computed tomography scanning of an intact specimen with microcomputed tomography and histological analysis of lung tissue samples, reported that the number of terminal bronchioles were reduced from approximately 44,500/lung pair in control (donor) lungs to approximately 4800/lung pair in lungs donated by individuals with very severe (Global initiative for chronic Obstructive Lung Disease stage 4) chronic obstructive pulmonary disease (COPD) treated by lung transplantation. The present short review discusses the hypothesis that a rapid rate of terminal bronchiolar destruction causes the rapid decline in lung function leading to advanced COPD. With respect to why the terminal bronchioles are targeted for destruction, the postulated mechanisms of this destruction and the possibility that new treatments are able to either prevent or reverse the underlying cause of airway obstruction in COPD are addressed.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research