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Objectives . The aim of this paper was to evaluate the cytotoxicity of Indonesian silkworm cocoon extract of  Cricula triphenestrata  on human fibroblasts.  Methods and Materials . The cocoon shells of the silkworm  Cricula triphenestrata  were degumming. The shells were mixed with an aqueous solution of 0.3% Na 2 CO 3  at 98°C for 1 hour. The solution was then dialyzed in cellulose membranes against deionized water for 3 days. The cocoon shells extract powder was collected via rotary evaporation and dried under freeze dryer. Cell culture medium was exposed to  Cricula triphenestrata  cocoon extract (0.01–100   μ  g/mL) for 24 hours. The primary human gingival fibroblasts were exposed to the treated cell culture medium for 24 hours. Cytotoxicity evaluation was done by MTT method. The data were analyzed by one-way ANOVA.  Result . The result revealed no significant cytotoxicity of  Cricula triphenestrata  cocoon extract against human fibroblasts at a concentration up to 100   μ  g/mL ( P  > 0.05).  Conclusion .  Cricula triphenestrata  cocoon extract was not cytotoxic on human gingival fibroblast cells.

Cytotoxicity ofCricula triphenestrataCocoon Extract on Human Fibroblasts