The Role of HLA in Cord Blood Transplantation | Zendy

Catherine StavropoulosGiokas | Zendy; Amalia Dinou | Zendy; Andreas Papassavas | Zendy

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The Role of HLA in Cord Blood Transplantation

Author(s) -

Catherine StavropoulosGiokas,

Amalia Dinou,

Andreas Papassavas

Publication year - 2012

Publication title -

bone marrow research

Language(s) - English

Resource type - Journals

eISSN - 2090-2999

pISSN - 2090-3006

DOI - 10.1155/2012/485160

Subject(s) - medicine , human leukocyte antigen , umbilical cord , cord blood , transplantation , hematopoietic stem cell transplantation , umbilical cord blood transplantation , immunology , haematopoiesis , immune system , disease , stem cell , graft versus host disease , histocompatibility , antigen , genetics , biology

In recent years, umbilical cord blood (CB), a rich source of hematopoietic stem cells (HSC), has been used successfully as an alternative HSC source to treat a variety of hematologic, immunologic, genetic, and oncologic disorders. CB has several advantages, including prompt availability of the transplant, decrease of graft versus host disease (GVHD) and better long-term immune recovery, resulting in a similar long-term survival. Studies have shown that some degree of HLA mismatches is acceptable. This review is intended to outline the main aspects of HLA matching in different settings (related, pediatric, adult, or double-unit HSCT), its effect on transplantation outcome and the role of HLA in donor selection.

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