Pharmacokinetics of Hyperthermic Intrathoracic Chemotherapy following Pleurectomy and Decortication | Zendy

Paul H. Sugarbaker | Zendy; O. Anthony Stuart | Zendy; Christopher Eger | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Pharmacokinetics of Hyperthermic Intrathoracic Chemotherapy following Pleurectomy and Decortication

Author(s) -

Paul H. Sugarbaker,

O. Anthony Stuart,

Christopher Eger

Publication year - 2012

Publication title -

gastroenterology research and practice

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.622

H-Index - 45

eISSN - 1687-630X

pISSN - 1687-6121

DOI - 10.1155/2012/471205

Subject(s) - medicine , pleurectomy , chemotherapy , abdomen , decortication , pharmacokinetics , doxorubicin , mitomycin c , mesothelioma , thorax (insect anatomy) , surgery , urology , peritoneal mesothelioma , pathology , anatomy

In patients with pseudomyxoma peritonei or peritoneal mesothelioma, direct extension of disease through the hemidiaphragm may result in an isolated progression of tumor within the pleural space. We monitored the intrapleural and plasma levels of mitomycin C and doxorubicin by HPLC assay in order to determine the pharmacokinetic behavior of this intracavitary use of chemotherapy. Our results showed a persistent high concentration of intrapleural drug as compared to plasma concentrations. The increased exposure for mitomycin C was 96, and the increased exposure for doxorubicin was 241. When the clearance of chemotherapy from the thoracic cavity was compared to clearance from the abdomen and pelvis, there was a considerably more rapid clearance from the abdomen as compared to the thorax. The pharmacologic study of intrapleural chemotherapy in these patients provides a strong pharmacologic rationale for regional chemotherapy in this group of patients.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research