Fatal Fulminant Hepatic Failure from Adenovirus in Allogeneic Bone Marrow Transplant Patients | Zendy

Jatin M. Vyas | Zendy; Wayne A. Marasco | Zendy

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Fatal Fulminant Hepatic Failure from Adenovirus in Allogeneic Bone Marrow Transplant Patients

Author(s) -

Jatin M. Vyas,

Wayne A. Marasco

Publication year - 2012

Publication title -

case reports in infectious diseases

Language(s) - English

Resource type - Journals

eISSN - 2090-6625

pISSN - 2090-6633

DOI - 10.1155/2012/463569

Subject(s) - medicine , fulminant hepatic failure , fulminant , bone marrow , immunohistochemistry , necrosis , bone marrow transplant , liver transplantation , bone marrow transplantation , pathology , liver failure , transplantation

We report two cases of fatal hepatic failure in patients who received matched unrelated bone marrow transplantation. Both patients presented with high fevers, abnormal liver functions tests, and hypodense lesions in the liver by CT scan. Histologic examination of postmortem liver samples demonstrated extensive necrosis, and immunohistochemistry was positive for adenovirus.

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