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While most patients with chronic myeloid leukemia (CML) express either e13a2 or e14a2  BCR-ABL1  transcripts, a significant minority expresses variant transcripts, of which e19a2 is the most common. Although considered to have a relatively favourable outcome, reported responses to tyrosine kinase inhibitor (TKI) therapy are variable with molecular monitoring in CML patients with e19a2  BCR-ABL1  transcripts rarely reported. A case of e19a2  BCR-ABL1  CML with marked thrombocytosis is described in which the value of molecular monitoring is emphasised during treatment interruptions, dose reductions, and changes. This case serves to demonstrate the requirement for prospective real-time quantitative PCR (RQ-PCR) assays for patients with variant  BCR-ABL1  transcript types and standardisation of such assays to enable modern patient management.

Chronic Myeloid Leukemia with e19a2BCR-ABL1Transcripts and Marked Thrombocytosis: The Role of Molecular Monitoring