Molecular Imaging in Breast Cancer: From Whole-Body PET/CT to Dedicated Breast PET
Author(s) -
Bas B. Koolen,
Wouter V. Vogel,
Marcus Peeters,
Claudette E. Loo,
Emiel J. Rutgers,
Renato A. Valdés Olmos
Publication year - 2012
Publication title -
journal of oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.228
H-Index - 54
eISSN - 1687-8469
pISSN - 1687-8450
DOI - 10.1155/2012/438647
Subject(s) - medicine , breast cancer , positron emission tomography , fluorodeoxyglucose , radiology , whole body imaging , pet ct , nuclear medicine , cancer
Positron emission tomography (PET), with or without integrated computed tomography (CT), using 18F-fluorodeoxyglucose (FDG) is based on the principle of elevated glucose metabolism in malignant tumors, and its use in breast cancer patients is frequently being investigated. It has been shown useful for classification, staging, and response monitoring, both in primary and recurrent disease. However, because of the partial volume effect and limited resolution of most whole-body PET scanners, sensitivity for the visualization of small tumors is generally low. To improve the detection and quantification of primary breast tumors with FDG PET, several dedicated breast PET devices have been developed. In this nonsystematic review, we shortly summarize the value of whole-body PET/CT in breast cancer and provide an overview of currently available dedicated breast PETs.
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