Effects of Cisplatin in Neuroblastoma Rat Cells: Damage to Cellular Organelles | Zendy

Giada Santin | Zendy; Luigi Scietti | Zendy; Paola Veneroni | Zendy; Sergio Barni | Zendy; Graziella Bernocchi | Zendy; Maria Grazia Bottone | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Effects of Cisplatin in Neuroblastoma Rat Cells: Damage to Cellular Organelles

Author(s) -

Giada Santin,

Luigi Scietti,

Paola Veneroni,

Sergio Barni,

Graziella Bernocchi,

Maria Grazia Bottone

Publication year - 2012

Publication title -

international journal of cell biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.587

H-Index - 53

eISSN - 1687-8884

pISSN - 1687-8876

DOI - 10.1155/2012/424072

Subject(s) - cisplatin , organelle , apoptosis , programmed cell death , microbiology and biotechnology , golgi apparatus , neuroblastoma , dna damage , cytotoxic t cell , cell , biology , cancer research , bioinformatics , chemistry , chemotherapy , cell culture , dna , endoplasmic reticulum , in vitro , biochemistry , genetics

Cisplatin (cisPt) is a chemotherapy agent used as a treatment for several types of cancer. The main cytotoxic effect of cisplatin is generally accepted to be DNA damage. Recently, the mechanism by which cisPt generates the cascade of events involved in the apoptotic process has been demonstrated. In particular it has been shown that some organelles are cisPt target and are involved in cell death. This paper aims to describe the morphological and functional changes of the Golgi apparatus and lysosomes during apoptosis induced in neuronal rat cells (B50) by cisplatin. The results obtained show that the cellular organelles are the target of cisPt, so their damage can induce cell death.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research