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Pilocytic astrocytoma (PA) is the most frequently encountered glial tumor (glioma or astrocytoma) in children. Recent studies have identified alterations in the  BRAF  serine/threonine kinase gene as the likely causative mutation in these childhood brain tumors. The majority of these genetic changes involve chromosome 7q34 tandem duplication, resulting in aberrant  BRAF  fusion transcripts. In this paper, we describe a novel  KIAA1549:BRAF  fusion transcript in a sporadic PA tumor associated with increased ERK activation and review the spectrum of  BRAF  genetic alterations in this common pediatric low-grade central nervous system neoplasm.

NovelBRAFAlteration in a Sporadic Pilocytic Astrocytoma