Immunotherapy of Genitourinary Malignancies | Zendy

Teruo Inamoto | Zendy; Haruhito Azuma | Zendy

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Immunotherapy of Genitourinary Malignancies

Author(s) -

Teruo Inamoto,

Haruhito Azuma

Publication year - 2012

Publication title -

journal of oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.228

H-Index - 54

eISSN - 1687-8469

pISSN - 1687-8450

DOI - 10.1155/2012/397267

Subject(s) - medicine , genitourinary system , immunotherapy , disease , chemotherapy , oncology , bladder cancer , radiation therapy , immune system , cancer , renal cell carcinoma , immunology

Most cancer patients are treated with some combination of surgery, radiation, and chemotherapy. Despite recent advances in local therapy with curative intent, chemotherapeutic treatments for metastatic disease often remain unsatisfying due to severe side effects and incomplete long-term remission. Therefore, the evaluation of novel therapeutic options is of great interest. Conventional, along with newer treatment strategies target the immune system that suppresses genitourinary (GU) malignancies. Metastatic renal cell carcinoma and non-muscle-invasive bladder caner represent the most immune-responsive types of all human cancer. This review examines the rationale and emerging evidence supporting the anticancer activity of immunotherapy, against GU malignancies.

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