Successful Treatment of Fanconi Anemia and T-Cell Acute Lymphoblastic Leukemia | Zendy

Terrie Flatt | Zendy; Kathleen Neville | Zendy; Karen Lewing | Zendy; Jignesh Dalal | Zendy

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Successful Treatment of Fanconi Anemia and T-Cell Acute Lymphoblastic Leukemia

Author(s) -

Terrie Flatt,

Kathleen Neville,

Karen Lewing,

Jignesh Dalal

Publication year - 2012

Publication title -

case reports in hematology

Language(s) - English

Resource type - Journals

eISSN - 2090-6560

pISSN - 2090-6579

DOI - 10.1155/2012/396395

Subject(s) - medicine , neutropenia , fanconi anemia , chemotherapy , aspergillosis , vincristine , anemia , methotrexate , cytarabine , leukemia , bone marrow , cyclophosphamide , oncology , immunology , biochemistry , chemistry , dna repair , gene

Fanconi anemia is associated with an increased risk of malignancy. Patients are sensitive to the toxic effects of chemotherapy. We report the case of a patient with Fanconi anemia who developed T-cell acute lymphoblastic leukemia. He experienced chemotherapy-related complications including prolonged neutropenia, grade IV vincristine neuropathy, and disseminated aspergillosis. He was successfully treated with modified dosing of cytarabine and intrathecal methotrexate followed by allogeneic bone marrow transplant. The aspergillosis was treated with systemic antifungal treatment and surgical resection. Now 30 months after bone marrow transplant the patient is without evidence of aspergillosis or leukemia.

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