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Versatile Microwave-Assisted and Lanthanum Chloride Catalysed Synthesis of Polysubstituted Imidazoles Using Urea/Thiourea as Benign Source of Ammonia
Author(s) -
Mohammadreza Manafi,
Pedram Manafi,
Mohammadreza Kalaee
Publication year - 2011
Publication title -
journal of chemistry
Language(s) - English
Resource type - Journals
eISSN - 2090-9063
pISSN - 2090-9071
DOI - 10.1155/2012/396127
Subject(s) - thiourea , lanthanum , ammonia , urea , chemistry , chloride , inorganic chemistry , nuclear chemistry , microwave , organic chemistry , combinatorial chemistry , computer science , telecommunications
Lanthanum chloride was found to be an effective catalyst for the facile and one-pot synthesis of polysubstituted imidazoles under solvent free condition in excellent yields. This method elucidates urea/thiourea, as an environmentally benign source of ammonia for the synthesis of polysubstituted imidazoles. The work-up procedure is very simple and the products don’t require further purification

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