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Purpose . The purpose of this paper is to evaluate a new PET tracer  64 Cu-NODAGA-c(RGDyK) for imaging of tumor angiogenesis using gene expression of angiogenesis markers as reference and to estimate radiation dosimetry for humans.  Procedures . Nude mice with human neuroendocrine tumor xenografts (H727) were administered  64 Cu-NODAGA-c(RGDyK) i.v. for study of biodistribution as well as for dynamic PET. Gene expression of angiogenesis markers integrin  α    V  , integrin  β   3 , and VEGF-A were analyzed using QPCR and correlated to the tracer uptake in the tumors (%ID/g). From biodistribution data human radiation-absorbed doses were estimated using OLINDA/EXM.  Results . Tumor uptake was 1.2%ID/g with strong correlations between gene expression and tracer uptake, for integrin  α    V     R  = 0.76, integrin  β   3    R  = 0.75 and VEGF-A  R  = 0.81 (all  P  < 0.05). The whole body effective dose for humans was estimated to be 0.038 and 0.029 mSv/MBq for females and males, respectively, with highest absorbed dose in bladder wall.  Conclusion .  64 Cu-NODAGA-c(RGDyK) is a promising new angiogenesis PET tracer with potential for human use.

international journal of molecular imaging

<sup>64</sup>Cu-NODAGA-c(RGDyK) Is a Promising New Angiogenesis PET Tracer: Correlation between Tumor Uptake and Integrin Expression in Human Neuroendocrine Tumor Xenografts

64Cu-NODAGA-c(RGDyK) Is a Promising New Angiogenesis PET Tracer: Correlation between Tumor Uptake and Integrin Expression in Human Neuroendocrine Tumor Xenografts

⁶⁴Cu-NODAGA-c(RGDyK) Is a Promising New Angiogenesis PET Tracer: Correlation between Tumor Uptake and Integrin Expression in Human Neuroendocrine Tumor Xenografts