Open AccessReductive Cleavage of 1,2-Oxazines Promoted by Zinc and Ammonium Chloride; Mild One Pot Preparation ofγ-Hydroxy Ketones
Author(s) -
Prabhat Kumar,
K. M. Lokanatha
Publication year - 2011
Publication title -
journal of chemistry
Language(s) - English
Resource type - Journals
eISSN - 2090-9063
pISSN - 2090-9071
DOI - 10.1155/2012/376935
Subject(s) - oxazines , zinc , ammonium chloride , chemistry , cleavage (geology) , chloride , ammonium , organic chemistry , materials science , fracture (geology) , composite material
A facile method for a mild single pot reductive cleavage of 1,2-oxazines to gamma-hydroxy ketones was developed using zinc and aqueous ammonium chloride as the reagent in methanol. The reaction involves the reduction of N-O bond of the oxazine and the hydrolysis of the resulting 1,4-iminoalcohol
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