Effect of an Oral Adsorbent, AST-120, on Dialysis Initiation and Survival in Patients with Chronic Kidney Disease | Zendy

Shingo Hatakeyama | Zendy; Hayato Yamamoto | Zendy; Akiko Okamoto | Zendy; Kengo Imanishi | Zendy; Noriko Tokui | Zendy; Teppei Okamoto | Zendy; Yuichiro Suzuki | Zendy; Naoaki Sugiyama | Zendy; Atsushi Imai | Zendy; Shigemasa Kudo | Zendy; Takahiro Yoneyama | Zendy; Yasuhiro Hashimoto | Zendy; Takuya Koie | Zendy; Noritaka Kaminura | Zendy; Hisao Saitoh | Zendy; Tomihisa Funyu | Zendy; Chikara Οhyama | Zendy

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Effect of an Oral Adsorbent, AST-120, on Dialysis Initiation and Survival in Patients with Chronic Kidney Disease

Author(s) -

Shingo Hatakeyama,

Hayato Yamamoto,

Akiko Okamoto,

Kengo Imanishi,

Noriko Tokui,

Teppei Okamoto,

Yuichiro Suzuki,

Naoaki Sugiyama,

Atsushi Imai,

Shigemasa Kudo,

Takahiro Yoneyama,

Yasuhiro Hashimoto,

Takuya Koie,

Noritaka Kaminura,

Hisao Saitoh,

Tomihisa Funyu,

Chikara Οhyama

Publication year - 2012

Publication title -

international journal of nephrology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.551

H-Index - 29

eISSN - 2090-2158

pISSN - 2090-214X

DOI - 10.1155/2012/376128

Subject(s) - dialysis , medicine , kidney disease , dialysis therapy , survival rate , kidney , retrospective cohort study , survival analysis , urology , gastroenterology

The oral adsorbent AST-120 has the potential to delay dialysis initiation and improve survival of patients on dialysis. We evaluated the effect of AST-120 on dialysis initiation and its potential to improve survival in patients with chronic kidney disease. The present retrospective pair-matched study included 560 patients, grouped according to whether or not they received AST-120 before dialysis (AST-120 and non-AST-120 groups). The cumulative dialysis initiation free rate and survival rate were compared by the Kaplan-Meier method. Multivariate analysis was used to determine the impact of AST-120 on dialysis initiation. Our results showed significant differences in the 12- and 24-month dialysis initiation free rate (P<0.001), although no significant difference was observed in the survival rate between the two groups. In conclusion, AST-120 delays dialysis initiation in chronic kidney disease (CKD) patients but has no effect on survival. AST-120 is an effective therapy for delaying the progression of CKD

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