Analysis and Algorithmic Generation of Hepatic Vascular Systems

A proper geometric model of the vascular systems in the liver is crucial for modeling blood flow, the connection between the organ and the rest of the organism. In vivo imaging does not provide sufficient details, so an algorithmic concept for extending measured vascular tree data is needed such that geometrically realistic structures can be generated. We develop a quantification of similarity in terms of different geometric features. This involves topological Strahler ordering of the vascular trees, statistical testing, and averaging. Invariant features are identified in human clinical in vivo CT scans. Results of the existing “Constrained Constructive Optimization” algorithm are compared to real vascular tree data. To improve bifurcation angles in the algorithmic results, we implement a postprocessing step calibrated to the measured features. This framework is finally applied to generate realistic additional details in a patient-specific hepatic vascular tree data set.