The Impact of PPARγGenetic Variants on IBD Susceptibility and IBD Disease Course | Zendy

Jessica Mwinyi | Zendy; Christa Grete-Wenger | Zendy; Jyrki J. Eloranta | Zendy; Gerd A. KullakUblick | Zendy

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The Impact of PPARγGenetic Variants on IBD Susceptibility and IBD Disease Course

Author(s) -

Jessica Mwinyi,

Christa Grete-Wenger,

Jyrki J. Eloranta,

Gerd A. KullakUblick

Publication year - 2012

Publication title -

ppar research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.164

H-Index - 49

eISSN - 1687-4765

pISSN - 1687-4757

DOI - 10.1155/2012/349469

Subject(s) - haplotype , inflammatory bowel disease , single nucleotide polymorphism , allele , disease , exon , crohn's disease , medicine , genetics , immunology , gene , biology , genotype

PPAR γ is a nuclear receptor that regulates numerous pathways including cytokine expression and immune responses and plays an important role in controlling colon inflammation. We aimed at determining the occurring PPARγ SNPs, at predicting the haplotypes, and at determining the frequency outcome in inflammatory bowel disease (IBD) patients in comparison with healthy controls. We determined genetic variants in the coding exons and flanking intronic sequences of the NR1C3 gene in 284 IBD patients and 194 controls and predicted NR1C3 haplotypes via bioinformatic analysis. We investigated whether certain NR1C3 variants are associated with susceptibility to IBD or its disease course. None of the detected 22 NR1C3 variants were associated with IBD. Two variants with allelic frequencies over 1% were included in haplotype/diplotype analyses. None of the NR3C1 haplotypes showed association with IBD development or disease course. We conclude that NR1C3 haplotypes are not related to IBD susceptibility or IBD disease activity.

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