Low-Level Detection of Poly(amidoamine) PAMAM Dendrimers Using Immunoimaging Scanning Probe Microscopy | Zendy

Chevelle A. Cason | Zendy; Thomas A. Fabré | Zendy; Andrew Buhrlage | Zendy; Kristi L. Haik | Zendy; Heather A. Bullen | Zendy

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Low-Level Detection of Poly(amidoamine) PAMAM Dendrimers Using Immunoimaging Scanning Probe Microscopy

Author(s) -

Chevelle A. Cason,

Thomas A. Fabré,

Andrew Buhrlage,

Kristi L. Haik,

Heather A. Bullen

Publication year - 2012

Publication title -

international journal of analytical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.352

H-Index - 16

eISSN - 1687-8779

pISSN - 1687-8760

DOI - 10.1155/2012/341260

Subject(s) - poly(amidoamine) , dendrimer , amidoamine , microscopy , chemistry , materials science , nanotechnology , polymer chemistry , medicine , pathology

Immunoimaging scanning probe microscopy was utilized for the low-level detection and quantification of biotinylated G4 poly(amidoamine) PAMAM dendrimers. Results were compared to those of high-performance liquid chromatography (HPLC) and found to provide a vastly improved analytical method for the low-level detection of dendrimers, improving the limit of detection by a factor of 1000 (LOD = 2.5 × 10 −13 moles). The biorecognition method is reproducible and shows high specificity and good accuracy. In addition, the capture assay platform shows a promising approach to patterning dendrimers for nanotechnology applications.

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