A Case of Severe Asthma with Eosinophilic Otitis Media Successfully Treated with Anti-IgE Monoclonal Antibody Omalizumab | Zendy

Azusa Okude | Zendy; Etsuko Tagaya | Zendy; Mitsuko Kondo | Zendy; Manabu aka | Zendy; Jun Tamaoki | Zendy

Open Access

A Case of Severe Asthma with Eosinophilic Otitis Media Successfully Treated with Anti-IgE Monoclonal Antibody Omalizumab

Author(s) -

Azusa Okude,

Etsuko Tagaya,

Mitsuko Kondo,

Manabu aka,

Jun Tamaoki

Publication year - 2012

Publication title -

case reports in pulmonology

Language(s) - English

Resource type - Journals

eISSN - 2090-6846

pISSN - 2090-6854

DOI - 10.1155/2012/340525

Subject(s) - omalizumab , medicine , asthma , otitis , immunoglobulin e , eosinophilic , algorithm , pediatrics , immunology , antibody , surgery , pathology , computer science

A 51-year-old woman had been receiving medical treatment for asthma since she was 21 years old. However, her asthma was poorly controlled despite treatment involving combination inhalation of high-dose corticosteroid and long-acting β 2 -aderenergic agonist (LABA) and regularly taking oral steroids. Hearing loss and otorrhea appeared at the age of 44, and she was given a diagnosis of eosinophilic otitis media (EOM) and received medical treatment. In 2007, symptoms of asthma and otitis media deteriorated. In December 2009, omalizumab therapy was started for refractory asthma. After 2 months of omalizumab treatment, not only asthma, but also hearing loss improved. It is suggested that early initiation of omalizumab therapy may inhibit the progression of progressive EOM.

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