Design, Synthesis and Docking Studies of a Novel Ciprofloxacin Analogue as an Antimicrobial AGENT | Zendy

Jubie Selvaraj | Zendy; Kalirajan Rajagopal | Zendy; Pavankumar Yadav | Zendy

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Design, Synthesis and Docking Studies of a Novel Ciprofloxacin Analogue as an Antimicrobial AGENT

Author(s) -

Jubie Selvaraj,

Kalirajan Rajagopal,

Pavankumar Yadav

Publication year - 2011

Publication title -

journal of chemistry

Language(s) - English

Resource type - Journals

eISSN - 2090-9063

pISSN - 2090-9071

DOI - 10.1155/2012/340451

Subject(s) - ciprofloxacin , autodock , antibacterial activity , antimicrobial , chemistry , proton nmr , gram , docking (animal) , combinatorial chemistry , solubility , minimum inhibitory concentration , stereochemistry , organic chemistry , bacteria , biochemistry , antibiotics , biology , medicine , genetics , nursing , in silico , gene

The carboxylic acid group of ciprofloxacin was modified and amino mercapto triazole was substituted. The compound was confirmed by physical parameters (solubility, melting point), chromatographic methods (TLC) and consistent with its IR & 1HNMR spectra. The synthesized analogue was screened for antibacterial activity against one gram positive & two gram negative species. The compound exhibited good antibacterial effect towards gram negative species when compared to the standard ciprofloxacin. At the same time the analogue was retaining antibacterial activity towards gram positive species when compared to standard ciprofloxacin. The molecular docking studies showed a good correlation between their antibacterial activity and autodock binding free energy

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