Open AccessModified Carbon Nanotube Paste Electrode for Voltammetric Determination of Carbidopa, Folic Acid, and Tryptophan
Author(s) -
Sakineh Esfandiari Baghbamidi,
Hadi Beitollahi,
Hassan KarimiMaleh,
Somayeh Soltani-Nejad,
Vahhab Soltaninejad,
Sara Roodsaz
Publication year - 2012
Publication title -
journal of analytical methods in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.407
H-Index - 25
eISSN - 2090-8865
pISSN - 2090-8873
DOI - 10.1155/2012/305872
Subject(s) - detection limit , carbidopa , electrode , reproducibility , carbon paste electrode , carbon nanotube , chemistry , folic acid , voltammetry , square wave , electrochemistry , cyclic voltammetry , tryptophan , chromatography , nuclear chemistry , analytical chemistry (journal) , materials science , nanotechnology , biochemistry , medicine , voltage , levodopa , amino acid , pathology , quantum mechanics , physics , disease , parkinson's disease
A simple and convenient method is described for voltammetric determination of carbidopa (CD), based on its electrochemical oxidation at a modified multiwall carbon nanotube paste electrode. Under optimized conditions, the proposed method exhibited acceptable analytical performances in terms of linearity (over the concentration range from 0.1 to 700.0 μ M), detection limit (65.0 nM), and reproducibility (RSD = 2.5%) for a solution containing CD. Also, square wave voltammetry (SWV) was used for simultaneous determination of CD, folic acid (FA), and tryptophan (TRP) at the modified electrode. To further validate its possible application, the method was used for the quantification of CD, FA, and TRP in urine samples.
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