Neonatal Lupus Erythematosus | Zendy

KamLun Ellis Hon | Zendy; Alexander K. C. Leung | Zendy

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Neonatal Lupus Erythematosus

Author(s) -

KamLun Ellis Hon,

Alexander K. C. Leung

Publication year - 2012

Publication title -

autoimmune diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.681

H-Index - 32

eISSN - 2090-0422

pISSN - 2090-0430

DOI - 10.1155/2012/301274

Subject(s) - medicine , pediatrics , tertiary care , autoantibody , ultrasonography , pathophysiology , multidisciplinary team , offspring , fetal echocardiography , pregnancy , intensive care medicine , fetus , antibody , immunology , surgery , prenatal diagnosis , nursing , biology , genetics

Neonatal lupus erythematosus (NLE) refers to a clinical spectrum of cutaneous, cardiac, and systemic abnormalities observed in newborn infants whose mothers have autoantibodies against Ro/SSA and La/SSB. The condition is rare and usually benign and self-limited but sometimes may be associated with serious sequelae. We review the pathophysiology, clinical features, and management of infants with this condition. Neonates with NLE should be managed at a tertiary care center. Multidisciplinary team involvement may also be indicated. In mothers with anti-Ro/SSA and/or anti-La/SSB antibodies and infants with congenital heart block, the risk of recurrence in subsequent offspring is 17–25%. Therefore, careful monitoring of subsequent pregnancies with serial ultrasonography and echocardiography is essential.

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