Focal Adhesion Kinases in Adhesion Structures and Disease | Zendy

Pierre P. Eleniste | Zendy; Angela Bruzzaniti | Zendy

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Focal Adhesion Kinases in Adhesion Structures and Disease

Author(s) -

Pierre P. Eleniste,

Angela Bruzzaniti

Publication year - 2012

Publication title -

journal of signal transduction

Language(s) - English

Resource type - Journals

eISSN - 2090-1739

pISSN - 2090-1747

DOI - 10.1155/2012/296450

Subject(s) - podosome , invadopodia , focal adhesion , paxillin , microbiology and biotechnology , proto oncogene tyrosine protein kinase src , ptk2 , extracellular matrix , integrin , tyrosine kinase , cell adhesion , adhesion , kinase , receptor tyrosine kinase , medicine , biology , signal transduction , cell , chemistry , cytoskeleton , biochemistry , protein kinase a , mitogen activated protein kinase kinase , organic chemistry , cancer , cancer cell

Cell adhesion to the extracellular matrix (ECM) is essential for cell migration, proliferation, and embryonic development. Cells can contact the ECM through a wide range of matrix contact structures such as focal adhesions, podosomes, and invadopodia. Although they are different in structural design and basic function, they share common remodeling proteins such as integrins, talin, paxillin, and the tyrosine kinases FAK, Pyk2, and Src. In this paper, we compare and contrast the basic organization and role of focal adhesions, podosomes, and invadopodia in different cells. In addition, we discuss the role of the tyrosine kinases, FAK, Pyk2, and Src, which are critical for the function of the different adhesion structures. Finally, we discuss the essential role of these tyrosine kinases from the perspective of human diseases.

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