-SSS/Lipiodol: Development of a Potential Treatment for HCC from Bench to Bedside
Author(s) -
Nicolas Lepareur,
Valérie Ardisson,
Nicolas Noiret,
Étienne Garin
Publication year - 2012
Publication title -
international journal of molecular imaging
Language(s) - English
Resource type - Journals
eISSN - 2090-1712
pISSN - 2090-1720
DOI - 10.1155/2012/278306
Subject(s) - lipiodol , medicine , hepatocellular carcinoma , radiation therapy , rhenium , medical physics , nuclear medicine , cancer research , oncology , surgery , inorganic chemistry , chemistry
Hepatocellular carcinoma (HCC) is the 5th most common tumour worldwide and has a dark prognosis. For nonoperable cases, metabolic radiotherapy with Lipiodol labelled with β -emitters is a promising therapeutic option. The Comprehensive Cancer Centre Eugène Marquis and the National Graduate School of Chemistry of Rennes (ENSCR) have jointly developed a stable and efficient labelling of Lipiodol with rhenium-188 (E β max = 2.1 MeV) for the treatment of HCC. The major “milestones” of this development, from the first syntheses to the recent first injection in man, are described.
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