Volumetric Diffuse Optical Tomography for Small Animals Using a CCD-Camera-Based Imaging System | Zendy

Zi-Jing Lin | Zendy; Haijing Niu | Zendy; Lin Li | Zendy; Hanli Liu | Zendy

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Volumetric Diffuse Optical Tomography for Small Animals Using a CCD-Camera-Based Imaging System

Author(s) -

Zi-Jing Lin,

Haijing Niu,

Lin Li,

Hanli Liu

Publication year - 2012

Publication title -

international journal of optics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.263

H-Index - 17

eISSN - 1687-9392

pISSN - 1687-9384

DOI - 10.1155/2012/276367

Subject(s) - imaging phantom , diffuse optical imaging , computer vision , compensation (psychology) , artificial intelligence , computer science , optical imaging , gamma camera , tomography , optics , iterative reconstruction , physics , psychology , psychoanalysis

We report the feasibility of three-dimensional (3D) volumetric diffuse optical tomography for small animal imaging by using a CCD-camera-based imaging system with a newly developed depth compensation algorithm (DCA). Our computer simulations and laboratory phantom studies have demonstrated that the combination of a CCD camera and DCA can significantly improve the accuracy in depth localization and lead to reconstruction of 3D volumetric images. This approach may present great interests for noninvasive 3D localization of an anomaly hidden in tissue, such as a tumor or a stroke lesion, for preclinical small animal models. Copyright © 2012 Zi-Jing Lin et al.

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